Microdialysis based research indicates that a conventional RA drug may help to treat breast cancer

发布日期:2011-2-27

2011-01-20
Microdialysis based research indicates that a conventional RA drug may help to treat breast cancer

In a recent study published in the January 2011 issue of Cancer Research, a Swedish research team headed by Professor Charlotta Dabrosin, concluded that breast cancer may be able to be treated by blocking an inflammatory protein by using a common  drug that used for treating Rheumatoid Arthritis (RA).

By using microdialysis in a model of human breast cancers in nude mice, the team was able to perform species-specific analyses of released proteins in the microenvironment. The team showed that tumors treated with tamoxifen and fed Flax or ENL exhibited decreased in vivo release of IL-1β derived from the murine stroma and decreased microvessel density whereas dietary GEN had no effects. Cancer cell–released IL-1Ra were approximately 5 times higher than stroma-derived
IL-1Ra.

The study concluded that it may be possible to treat breast cancer with the RA drug. Additional clinical trials are needed to prove safety and efficacy.

For more info on the study, see here